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Gene Expression across Normal and Tumor tissue
 
 
 
 
 
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  Analysis >> member of the ErbB protein family (ERBB2)
 
 ERBB2 (HER2) is a member of the ErbB protein family, and is over-expressed in approximately 25-30% of breast cancer patients. Herceptin (trastuzumab) is a monoclonal antibody targeting ERBB2 over-expressing breast cancer patients. Over-expression of ERBB2 also occurs in other cancers such as lung, ovarian, and stomach cancer.

1. The pattern of ERBB2 in diverse tumor and normal tissues (U133Plus2 data set)

2. The pattern of ERBB2 in diverse tumor and normal tissues (U133A data set)

 Both 1 and 2 clearly demostrate the over-expression of ERBB2 in a subsest of breast cancer patients as well as other cancer types such as lung, ovarian, and stomach cancers.

3. The pattern of ERBB2 in diverse cancer cell lines (U133Plus2 data set)

4. The pattern of ERBB2 in diverse cancer cell lines (U133A data set)

 Interestingly, the pattern of ERBB2 expression in diverse tissues are recapitulated in cell lines, so a subset of breast, esophageal, lung, ovarian, and stomach cancer cell lines over-express ERBB2 (3 and 4). This information is especially useful when one selects cancer cell lines for in vitro siRNA (or shRNA) knockdown experiment.

Data Summary
 • Data sets
  - U133Plus2 : 306
- U133A : 241
 • Samples
  - U133Plus2 : 24,300
- U133A : 16,400
 • Probes
  - U133Plus2 : 54,613
- U133A : 22,215
 
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